Recurrent Giant Cell Tumor of Sacrum Treated with Denosumab: A Case Report

Volume 7 | Issue 2 | May – August 2019 | Page: 38-42 | Pramod Chinder, Suresh Rao, Naveen Joseph Mathai, Manjeshwar Shrinath Baliga


Authors: Pramod Chinder [1], Suresh Rao [2], Naveen Joseph Mathai [3], Manjeshwar Shrinath Baliga [2].

[1] Department of Ortho-Oncology, Mangalore Institute of Oncology, Mangalore, Karnataka India,
[2] Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore, Karnataka India,
[3] Department of Trauma andOrthopaedics, University Hospital of Wales, Cardiff, UK.

Address of Correspondence
Dr. Suresh Rao,
Department of Radiation oncology,
Mangalore institute of Oncology, Mangalore
E-mail: raos_64@yahoo.com


Abstract

Giant cell tumor of the bone (GCTB) is a benign but locally aggressive tumor which has a predilection for the epiphyseo-metaphyseal region of long bones. However, the occurrence of GCT in surgically inaccessible locations such as the vertebrae and pelvis poses a daunting challenge. Receptor activator of nuclear factor kappa-B (RANK)-ligand binder, denosumab is a fully human monoclonal antibody which inhibits cells which expresses RANK ligand which is expressed in GCT. We report an unusual case report of recurrent GCT arising from the sacrum in a young man treated with denosumab. He underwent administration of denosumab pre-operatively and post-operatively whereby there was remission of the tumor. As a measure of “success,” we indicate the social functioning-36 and WHO questionnaire which indicate a good quality of life.
Keywords: Giant cell tumor of the bone, denosumab, sacrum.


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How to Cite this article: Chinder P, Rao S, Mathai N J, Shrinath Baliga M S. Recurrent Giant Cell Tumor of Sacrum Treated with Denosumab: A Case Report. Journal of Karnataka Orthopaedic Association. May-Aug 2019; 7(2): 38-42.

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