The Results of Synthetic Pure Calcium Sulfate Impregnated with Antibiotic in the Management of Bone Infections and Non-unions

Volume 7 | Issue 2 | May – Aug 2019 | Page: 22-26 | Keith B. Tamboowalla, Jaison Thomas, Madan Mohan M, Anoop Pilar, Belliappa C P, Rajkumar S Amaravathi

Authors: Keith B. Tamboowalla [1], Jaison Thomas [2], Madan Mohan M [3], Anoop Pilar [3], Belliappa C P [3], Rajkumar S Amaravathi [3].

[1] Department of Orthopaedics, St Johns Medical College Hospital, Bengaluru, Karnataka.

Address of Correspondence
Dr. Dr. Rajkumar S Amaravathi,
Professor and Unit Head,
Department of Orthopaedics, St Johns Medical College Hospital, Bengaluru, Karnataka.


Background: The problems in treating bone infections and non-unions of the bone continue to plague orthopedic practice. The authors present a retrospective analysis with the purpose of evaluating the outcome of infections and non-unions treated with antibiotic-impregnatedcalcium sulfate (AICS).
Materials and Methods: We assessed the outcomes of 25 patients who were operated between May 2014 and May 2017 for osteomyelitis (9) and long bone non-union (16). Each patient underwent a standard surgical procedure as the situation demanded, along with instillation of AICS into the defect. The outcomes measured were the presence of infection and union.
Results: At 1-year follow-up, 8 (88.89%) of the osteomyelitis patients showed good radiographic healing and no recurrence, while one had a relapse of osteomyelitis. Fourteen (87.5%) of the non-union patients had successful union, while persistent non-union developed in twopatients. Twenty-three (92%) patients had returned to full independent activities of daily living, including 19 who had returned to unrestricted leisure activities and pre-operative employment status.
Conclusions: We report the results of the use of AICS in our series, which showed high union rates and eradication of infection. Our experience shows that the use of AICS offers numerous advantages and promises in treating these conditions, which merit further study.
Keywords: Osteomyelitis, infected non-union, calcium sulfate, bone graft substitute, Stimulan, Fracture healing


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How to Cite this article: Tamboowalla K B, Thomas J, Madan Mohan M, Pilar A, Belliappa C P, Amaravathi R S. The Results of Synthetic Pure Calcium Sulfate Impregnated with Antibiotic in the Management of Bone Infections and Non-unions. Journal of Karnataka Orthopaedic Association. May-Aug 2019; 7(2): 22-26

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